Cocaine Annotated Bibliography

1.

O’Leary, M. E. & Chahine, M. Cocaine binds to a common site on open and inactivated human heart (Na(v)1.5) sodium channels. J. Physiol. (Lond.) 541, 701–716 (2002).

An amazing paper, extremely useful for its theory of sodium ion channel binding and conformational change

2.

O’Leary, M. E. & Hancox, J. C. Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmias. Br J Clin Pharmacol 69, 427–442 (2010).

Another great paper, delving into mechanism of sodium ion channel inhibition

3.

Heard, K., Cleveland, N. R. & Krier, S. Benzodiazepines and antipsychotic medications for treatment of acute cocaine toxicity in animal models – A systematic review and meta-analysis. Hum Exp Toxicol 30, 1849–1854 (2011).

Wonderful source for treatments

4.

Schwartz, B. G., Rezkalla, S. & Kloner, R. A. Cardiovascular Effects of Cocaine. Circulation 122, 2558–2569 (2010).

Delves into effects of adrenergic signaling on cocain-induced heart attacks

5.

Olsen, R. W. & DeLorey, T. M. GABA Receptor Physiology and Pharmacology. (1999). at <http://www.ncbi.nlm.nih.gov/books/NBK28090/>

Useful for understanding why Benzodiazepines are so useful as  general response to adrenergic signaling in cocaine

6.

Kerns, W., 2nd, Garvey, L. & Owens, J. Cocaine-induced wide complex dysrhythmia. J Emerg Med 15, 321–329 (1997).

Explains how dysfunction of sodium ion channels causes dysrhythmia.

7.

Lange, R. A. et al. Cocaine-induced coronary-artery vasoconstriction. N. Engl. J. Med. 321, 1557–1562 (1989).

Discusses one of the major causes of ischemia and increased O­­2 consumption

8.

Kukovetz, W. R., Holzmann, S. & Romanin, C. Mechanism of vasodilation by nitrates: role of cyclic GMP. Cardiology 74 Suppl 1, 12–19 (1987).

Explains why and how Nitrates may be used as a vasodilator and thus a treatment for cocain

9.

Brogan, W. C., 3rd, Lange, R. A., Kim, A. S., Moliterno, D. J. & Hillis, L. D. Alleviation of cocaine-induced coronary vasoconstriction by nitroglycerin. J. Am. Coll. Cardiol. 18, 581–586 (1991).

Further explanation regarding the use of nitrates, particular nitroglycerin

10.

Gootenberg, P. Cocaine : Global Histories. (Routledge, 1999). at <http://site.ebrary.com/lib/alltitles/docDetail.action?docID=5001420>

Created a depiction of cocaine use throughout the world

11.

Jonkman, S. & Kenny, P. J. Molecular, Cellular, and Structural Mechanisms of Cocaine Addiction: A Key Role for MicroRNAs.Neuropsychopharmacology 38, 198–211 (2013).

Explains mechanism of addiction and some of the best information we have currently

12.

Jeffrey Albores & Eric C. Kleerup. in D47. CASE VIGNETTES IN CRITICAL CARE I A6121–A6121 (American Thoracic Society, 2014). at <http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2014.189.1_MeetingAbstracts.A6121>

Discusses method of treating cocaine in cases of body packing

13.

Fukumi, D. S. Cocaine Trafficking in Latin America: EU and US Policy Responses. (Ashgate Publishing, Ltd., 2013).

History of cocaine use in US

14.

FFFLM, S. B. K., MD. A Brief History of Cocaine, Second Edition. (CRC Press, 2005).

History of cocaine use in the world, particularly in Incan culture

15.

Teli, K. J. et al.ARRHYTHMOGENIC EFFECTS OF COCAETHYLENE IN ALCOHOL AND COCAINE USERS. J Am Coll Cardiol59, E730–E730 (2012).

Discusses how the combination of cocaine and alcohol causes increased toxicity in users of this combinatorial drug

16.

Laizure, S. C., Mandrell, T., Gades, N. M. & Parker, R. B. Cocaethylene Metabolism and Interaction with Cocaine and Ethanol: Role of Carboxylesterases.Drug Metab Dispos 31,16–20 (2003).

Discusses how the metabolism of cocaine changes after ethanol is given

17.
Willenheimer, R. & Erdmann, E. Chairmen’s Foreword: beta-blockade across the cardiovascular continuum—when and where to use? at <http://eurheartjsupp.oxfordjournals.org>

Creates a wonderful graph on the use of beta-blockers

18.

Kolbrich, E. A. et al. Major and Minor Metabolites of Cocaine in Human Plasma following Controlled Subcutaneous Cocaine Administration. J Anal Toxicol30, 501–510 (2006).

This study shows the rates of metabolism of cocaine to its major and minor components in human subjects, supporting our knowledge of the pharmacokinetics of cocaine. This study demonstrates an area where further testing is necessary since no pharmacokinetics of cocaine metabolism alongside alcohol consumption has been studied in humans.

19.

Payandeh, J., Scheuer, T., Zheng, N. & Catterall, W. A. The crystal structure of a voltage-gated sodium channel. Nature 475, 353–358 (2011).

An exciting x-ray crystal structure of sodium channel at 2.7 angstroms, quite useful for potentially characterizing its inhibition.