Biochemistry @ Muhlenberg

BCM 441 Advanced Biochemistry

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Month: March 2018

APC/C

SUMOylation: Wrestling with the Regulation of APC/C

Posted on March 29, 2018 by Calvin Inners

Author: Calvin Inners The paper can be accessed here: https://www.nature.com/articles/s41467-018-03486-4   The image above depicts the SUMOylation and ubiquitination of ACP/C through its APC4 domain…

BCM441

An E3 ubiquitin ligase is essential for immune homeostasis

Posted on March 24, 2018 by Brandon Eden

Author: Brandon Eden TRIM29, an E3 ubiquitin ligase as depicted in the above figure, tags STING for proteasome-dependent degradation to downregulate the antiviral cystolic DNA…

BCM441

Calcium Imaging; New way to identify AβO targets

Posted on March 23, 2018 by Endonita Hajzeraj

Author: Endonita Hajzeraj AβOs or soluble amyloid β oligomers are recognized by the public as neurotoxins that trigger divergent signaling in neurons. This signaling of…

The Oncogenic Role of USP4, a deubiquitinase, in Melanoma
BCM 441

The Oncogenic Role of USP4, a deubiquitinase, in Melanoma

Posted on March 18, 2018 by Camille Jessica Cunanan

Author: Camille Jessica Cunanan Skin cancer is the most common form of cancer in the United States, surpassing cancers of the breasts and lungs (1).…

BCM 441

The Oncogenic Role of USP4, a deubiquitinase, in Melanoma

Posted on March 18, 2018 by Camille Jessica Cunanan

Author: Camille Jessica Cunanan Skin cancer is the most common form of cancer in the United States, surpassing cancers of the breasts and lungs (1).…

BCM 441

The Oncogenic Role of USP4, a deubiquitinase, in Melanoma

Posted on March 18, 2018 by Camille Jessica Cunanan

Author: Camille Jessica Cunanan Skin cancer is the most common form of cancer in the United States, surpassing cancers of the breasts and lungs (1).…

BCM 441

The Oncogenic Role of USP4, a deubiquitinase, in Melanoma

Posted on March 18, 2018 by Camille Jessica Cunanan

Author: Camille Jessica Cunanan Skin cancer is the most common form of cancer in the United States, surpassing cancers of the breasts and lungs (1).…

BCM441

Reviewing the Primary Literature of FOP

Posted on March 17, 2018 by Andrew Rice

Author: Andrew Rice After diving into the literature of fibrodysplasia ossificans progressiva (FOP), I have begun to understand this debilitating disease. The sources I have…

BCM441

Not So Toxic After All: How Cancer Cells Benefit from Ammonia

Posted on March 15, 2018 by Brandon Copping

Author: Brandon Copping This figure shows the glutaminolysis pathway and the predicted mechanism for how cancer cells are able to reincorporate ammonia into producing building…

BCM441

Reflection Blog 3 – Review Article Organization

Posted on March 15, 2018 by Calvin Inners

Author: Calvin Inners By searching through the literature, I was able to focus my topic to the TMPRSS2-ERG mutation in prostate cancer. I will start…

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This site aggregates the scholarly work of students enrolled in BCM 441 at Muhlenberg College with Dr. Keri Colabroy. Students blog on the latest, high-impact science and explore the mechanism of human disease in depth.

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