a, Cryo-EM density at contour level of 0.055 (C2 map), shown in transparent surface. Proteins are depicted as cartoon models. Owing to low resolution in…
Fig. 3 TRIM32, USP7 and cMyc directly interact with each other and USP7 shows the same expression pattern as TRIM32 in proliferating cells of the…
There is currently an obesity epidemic that is facing not only the United States, but the entire world. From 1975 to 2016, children and young…
Original Paper: Multi-omics analysis of multiple missions to space reveal a theme of lipid dysregulation in mouse liver Life on Earth is the achievement of…
Original Paper: Jones ST, Cagno V, Janeček M, et al. Modified cyclodextrins as broad-spectrum antivirals. Sci Adv. 2020;6(5):eaax9318. doi:10.1126/sciadv.aax9318 – https://advances.sciencemag.org/content/6/5/eaax9318 Viral infections are very…
Lipids for Life 95 SH-directed inhibitors were screened for their effect on C. elegans lifespan. Screening was done in 96-well plates and compounds were generally…
If you’ve ever been to the doctor and diagnosed with a bacterial infection, you were probably prescribed an antibiotic. From their discovery in the early…
Figure 1. This is an illustration of how the rhomboid proteases distort membranes which do not fit their hydrophobic belt. A typical transmembrane protein is…
An Immunologists Approach A stipulation of any aspiring research immunologist is perhaps a somewhat unnatural and overly effervescent fascination for therapeutic target discovery. The most…
I’ve come up with a few possible choices for my disease project topic. There is one clear winner, as I will soon divulge. The choices…
