Lipopolysaccharides (LPS), when they interact with the Toll-like receptor-4 (TLR4)-myeloid differentiation factor 2 (MD-2) complex, lead to a signaling cascade that results in a…
By Hudson Roth Spotlight #1 Matsumori, N. et al. Biochemistry 2013, 52, 2410-2418. Natural products isolated from plants, bacteria, and marine organisms serve as an…
Paper: Cell survival during Complete Nutrient Deprivation Depends on Lipid Droplet-fueled β-oxidation of Fatty Acids. http://www.jbc.org/content/288/39/27777.full.pdf+html?sid=958a2e65-ca82-45c9-91e3-561a3cd2278e A Dying Cell’s Last Hope: β-Oxidation of Lipid Droplets…
The human body obtains energy through the breakdown of fatty acids, which are often stored as a complex called triacylglycerol. In order to initiate the…
Enzyme regulation is an important process in controlling metabolic flux. The two ways in which this is thought to happen is by inhibiting an enzyme…
By Evan Gassaway Paper: Metabolic regulation of Nucleo-cytosolic Trafficking of Carbohydrate Response Element-binding Protein (ChREBP): Role of Ketone Bodies http://www.jbc.org/content/288/39/28368 ChREBP (carbohydrate response element-binding protein)…
By Edward Quach Paper: Cohen, T. J. et al. The acetylation of tau inhibits its function and promotes pathological tau aggregation. Nat Com. 2, 252…
By Hudson Roth Spotlight #2 Zheng, H. et al. Biochemistry 2013, 52, 5876-5883. http://pubs.acs.org/doi/pdf/10.1021/bi400821s In recent years there has been an increasing interest in biocatalysis,…
By Ian Smith Paper: Vinylogous chain branching catalysed by a dedicated polyketide synthase module http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12588.html Creating complex naturally-occurring compounds biosynthetically, by mimicking prokaryotic metabolism, is…
