I may or may not have typed “biochemical diseases” into Google before considering the following:
- Acute myeloid leukemia- Over the summer, I worked with an oncologist at one of the Lehigh Valley Health Network hospitals reviewing acute myeloid leukemia (AML) cases treated by the hospital network. Through this opportunity, I was able to learn about the clinical implications of the disease-symptoms, diagnosis, treatments, survival, etc- but I neglected to learn about the biochemistry of the disease! I would love to look at AML from a biochemical standpoint and then connect them to the clinical implications I have learned about and maybe even consider new connections.
- Schizophrenia- For some reason, I find schizophrenia really fascinating, maybe because I took one neuroscience class junior year. Schizophrenia is a severe mental illness characterized by disordered thinking and behavior with decreased motivation and cognitive deficits in attention and memory1. For the neuroscience class, I wrote a review paper on the characterization of the dopamine receptor and its role in schizophrenia. It would be interesting to further research the dopamine pathway in its relation to the disease.
- Celiac Disease- This is for my roommate who informs EVERYONE, EVERYDAY that she is allergic to gluten. Maybe if I research the disease and discover something, I can relay that the information to her (disclaimer: she does not actually have celiac disease, but is gluten intolerant).
- Labrie V, Clapcote SJ, Roder JC. Mutant mice with reduced NMDA-NR1 glycine affinity or lack of d-amino acid oxidase function exhibit altered anxiety-like behaviors. Pharmacology Biochemistry and Behavior. 2009, 91(4), 610-620.
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