Biochemistry @ Muhlenberg

BCM 441 Advanced Biochemistry

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Category: Pathway regulation

Osmotin as a Novel Drug for the Prevention of Alzheimer's Disease
Neurodegenerative Disease

Osmotin as a Novel Drug for the Prevention of Alzheimer's Disease

Posted on April 2, 2016December 22, 2016 by elliottgoldberg

Alzheimer’s disease is a progressive brain disorder that impairs cognitive function and destroys memory in older adults. It is characterized even in its earliest stages…

Migration and Polysialylation
Cancer

Migration and Polysialylation

Posted on February 19, 2016December 22, 2016 by elainegersz

Elaine Gersz ChemBio Spotlight #2 Paper: Polysialylation Controls Dendritic Cell Trafficking by Regulation Chemokine Recognition http://science.sciencemag.org/content/351/6269/186 Polysialic acid (PolySia) has been shown to foster cancer…

GRK-2: A Potential Target for Therapeutic Drugs Treating Heart Failure
Pathway regulation

GRK-2: A Potential Target for Therapeutic Drugs Treating Heart Failure

Posted on February 6, 2016 by zacharygallagher

Zachary Gallagher Chembio spotlight #1 Paper: Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase http://www.jbc.org/content/291/6/2583 GRK-2: A…

'Stear'ing Down the New Mitochondrial Regulatory Pathway
Neurodegenerative Disease

'Stear'ing Down the New Mitochondrial Regulatory Pathway

Posted on February 3, 2016December 22, 2016 by elainegersz

Everyone knows that mitochondria are the powerhouse of the cell. However, mitochondria are also involved in a variety of cellular processes such as amino acid…

Getting to the Heart of the Matter: The role of PKA in Plin-5 regulated lipolysis in cardiac muscle
Enzyme Mechanism

Getting to the Heart of the Matter: The role of PKA in Plin-5 regulated lipolysis in cardiac muscle

Posted on January 31, 2015 by Kelly Cann

Kelly Cann ChemBio Spotlight Week 3 Paper:The Interplay of Protein Kinase A and Perilipin 5 Regulates Cardiac Lipolysis Getting to the Heart of the Matter:…

It’s All in the Genes: KSR2’s Role in Weight Regulation
Pathway regulation

It’s All in the Genes: KSR2’s Role in Weight Regulation

Posted on March 10, 2014 by Ramzy

By: Ramzy Burns Paper: KSR2 Mutations Are Associated with Obesity, Insulin Resistances, and Impaired Cellular Fuel Oxidation http://download.cell.com/mmcs/journals/00928674/PIIS0092867413012762.mmc3.pdf With obesity rates steadily climbing, understanding the…

Pathway regulation

Novel Antidiabetic Mechanism that Prevents Hypoglycemia

Posted on March 10, 2014 by iansmith

Novel Antidiabetic Mechanism that Prevents Hypoglycemia http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12724.html Hyperglycemia and type II diabetes meillitus are serious medical conditions that can be due to the disruption of…

Pathway regulation

ATF4, Maybe Less Really Is More

Posted on March 10, 2014 by Tyler Littmann

ATF4 Protein Deficiency Protects against High Fructose-induced Hypertriglyceridemia in Mice http://www.jbc.org/content/288/35/25350.full This article investigated the causes and effects of lipogenesis and it’s impact on the…

Distinguishing the Functions of GPAT1 and GPAT4
Pathway regulation

Distinguishing the Functions of GPAT1 and GPAT4

Posted on March 10, 2014 by dominiclapadula

The human body obtains energy through the breakdown of fatty acids, which are often stored as a complex called triacylglycerol. In order to initiate the…

Functional Lysine Modification by an Intrinsically Reactive Primary Glycolytic Metabolite
Pathway regulation

Functional Lysine Modification by an Intrinsically Reactive Primary Glycolytic Metabolite

Posted on March 10, 2014 by Matthew Bocchese

Enzyme regulation is an important process in controlling metabolic flux.  The two ways in which this is thought to happen is by inhibiting an enzyme…

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This site aggregates the scholarly work of students enrolled in BCM 441 at Muhlenberg College with Dr. Keri Colabroy. Students blog on the latest, high-impact science and explore the mechanism of human disease in depth.

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