Alzheimer’s disease is a progressive brain disorder that impairs cognitive function and destroys memory in older adults. It is characterized even in its earliest stages…
Category: Pathway regulation
Elaine Gersz ChemBio Spotlight #2 Paper: Polysialylation Controls Dendritic Cell Trafficking by Regulation Chemokine Recognition http://science.sciencemag.org/content/351/6269/186 Polysialic acid (PolySia) has been shown to foster cancer…
Zachary Gallagher Chembio spotlight #1 Paper: Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase http://www.jbc.org/content/291/6/2583 GRK-2: A…
Everyone knows that mitochondria are the powerhouse of the cell. However, mitochondria are also involved in a variety of cellular processes such as amino acid…
Kelly Cann ChemBio Spotlight Week 3 Paper:The Interplay of Protein Kinase A and Perilipin 5 Regulates Cardiac Lipolysis Getting to the Heart of the Matter:…
By: Ramzy Burns Paper: KSR2 Mutations Are Associated with Obesity, Insulin Resistances, and Impaired Cellular Fuel Oxidation http://download.cell.com/mmcs/journals/00928674/PIIS0092867413012762.mmc3.pdf With obesity rates steadily climbing, understanding the…
Novel Antidiabetic Mechanism that Prevents Hypoglycemia http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12724.html Hyperglycemia and type II diabetes meillitus are serious medical conditions that can be due to the disruption of…
ATF4 Protein Deficiency Protects against High Fructose-induced Hypertriglyceridemia in Mice http://www.jbc.org/content/288/35/25350.full This article investigated the causes and effects of lipogenesis and it’s impact on the…
The human body obtains energy through the breakdown of fatty acids, which are often stored as a complex called triacylglycerol. In order to initiate the…
Enzyme regulation is an important process in controlling metabolic flux. The two ways in which this is thought to happen is by inhibiting an enzyme…
