Biochemistry @ Muhlenberg

BCM 441 Advanced Biochemistry

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Everything that Goes Up Must Come Down: Closer Examination of Previous Work Demonstrates the Importance of in cellulo Experiments
Treatment and Disease management

Everything that Goes Up Must Come Down: Closer Examination of Previous Work Demonstrates the Importance of in cellulo Experiments

Posted on April 30, 2014 by Katerina Pham

Paper: In Cellulo Examination of a β-α Hybrid Construct of β-Hexosamindase A Subunits, Reported to Interact with the GM2 Activator Protein and Hydrolyze GM2 Ganglioside…

Treatment and Disease management

Major Depressive Disorder

Posted on April 24, 2014 by markscheuerman

                                Major Depressive disorder (MDD) is a disease that affects…

Uncategorized

Cocaine Title Page

Posted on April 24, 2014 by Cyrus E. Kuschner

Cocaine is a highly addictive recreational drug, traditionally extracted from the coca plant grown in south America and more recently Columbia.  This drug was commonly used…

Neurodegenerative Disease

What is Phenylketonuria?

Posted on April 24, 2014 by iansmith

Phenylketonuria (PKU) is an autosomal recessive genetic disorder that is inherited due to a contribution of the genetic disorder gene from each parent. Phenylketonuria is…

It’s All in the Genes: KSR2’s Role in Weight Regulation
Pathway regulation

It’s All in the Genes: KSR2’s Role in Weight Regulation

Posted on March 10, 2014 by Ramzy

By: Ramzy Burns Paper: KSR2 Mutations Are Associated with Obesity, Insulin Resistances, and Impaired Cellular Fuel Oxidation http://download.cell.com/mmcs/journals/00928674/PIIS0092867413012762.mmc3.pdf With obesity rates steadily climbing, understanding the…

From chromatin to carbohydrates: bridging the gap with β-hydroxybutyrate
Epigenetics and metabolism

From chromatin to carbohydrates: bridging the gap with β-hydroxybutyrate

Posted on March 10, 2014 by Rebecca

  By Rebecca Golden Paper: Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylases inhibitor http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735349/ A cell must be able to adjust its genomic programming…

Cancer

Senescence: How a Cell’s World Comes to Stop when the K-ras Moves in

Posted on March 10, 2014 by Cyrus E. Kuschner

Among the cell’s many mechanisms to stop the aberrant cell proliferation characterized in cancer is the activation of Oncogene-induced senescence (OIS), which stops cells from…

Giving Meningitis the Cold Shoulder: The development of structural mimics of naturally occurring N. meningtidis A antigens
Treatment and Disease management

Giving Meningitis the Cold Shoulder: The development of structural mimics of naturally occurring N. meningtidis A antigens

Posted on March 10, 2014 by rani

Spotlight #2, Radhika Rani Immunoactivity of Protein Conjugates of Carba Analogues from Neisseria meningitidis A Capsular Polysaccharide ACS Chem. Biol., 2013, 8 (11), pp 2561–2567 http://pubs.acs.org/doi/pdf/10.1021/cb400463u Of the…

Pathway regulation

Novel Antidiabetic Mechanism that Prevents Hypoglycemia

Posted on March 10, 2014 by iansmith

Novel Antidiabetic Mechanism that Prevents Hypoglycemia http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12724.html Hyperglycemia and type II diabetes meillitus are serious medical conditions that can be due to the disruption of…

Pathway regulation

ATF4, Maybe Less Really Is More

Posted on March 10, 2014 by Tyler Littmann

ATF4 Protein Deficiency Protects against High Fructose-induced Hypertriglyceridemia in Mice http://www.jbc.org/content/288/35/25350.full This article investigated the causes and effects of lipogenesis and it’s impact on the…

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This site aggregates the scholarly work of students enrolled in BCM 441 at Muhlenberg College with Dr. Keri Colabroy. Students blog on the latest, high-impact science and explore the mechanism of human disease in depth.

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