Phenylketonuria (PKU) is an autosomal recessive genetic disorder that is inherited due to a contribution of the genetic disorder gene from each parent. Phenylketonuria is…
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By: Ramzy Burns Paper: KSR2 Mutations Are Associated with Obesity, Insulin Resistances, and Impaired Cellular Fuel Oxidation http://download.cell.com/mmcs/journals/00928674/PIIS0092867413012762.mmc3.pdf With obesity rates steadily climbing, understanding the…
By Rebecca Golden Paper: Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylases inhibitor http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735349/ A cell must be able to adjust its genomic programming…
Among the cell’s many mechanisms to stop the aberrant cell proliferation characterized in cancer is the activation of Oncogene-induced senescence (OIS), which stops cells from…
Spotlight #2, Radhika Rani Immunoactivity of Protein Conjugates of Carba Analogues from Neisseria meningitidis A Capsular Polysaccharide ACS Chem. Biol., 2013, 8 (11), pp 2561–2567 http://pubs.acs.org/doi/pdf/10.1021/cb400463u Of the…
Novel Antidiabetic Mechanism that Prevents Hypoglycemia http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12724.html Hyperglycemia and type II diabetes meillitus are serious medical conditions that can be due to the disruption of…
ATF4 Protein Deficiency Protects against High Fructose-induced Hypertriglyceridemia in Mice http://www.jbc.org/content/288/35/25350.full This article investigated the causes and effects of lipogenesis and it’s impact on the…
Lipopolysaccharides (LPS), when they interact with the Toll-like receptor-4 (TLR4)-myeloid differentiation factor 2 (MD-2) complex, lead to a signaling cascade that results in a…
By Hudson Roth Spotlight #1 Matsumori, N. et al. Biochemistry 2013, 52, 2410-2418. Natural products isolated from plants, bacteria, and marine organisms serve as an…
Paper: Cell survival during Complete Nutrient Deprivation Depends on Lipid Droplet-fueled β-oxidation of Fatty Acids. http://www.jbc.org/content/288/39/27777.full.pdf+html?sid=958a2e65-ca82-45c9-91e3-561a3cd2278e A Dying Cell’s Last Hope: β-Oxidation of Lipid Droplets…
